Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches (AAPS Advances in the Pharmaceutical Sciences Series, 33) [Hardcover] de Lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta and Thorne, Robert G. fbm transformative insights

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Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches (AAPS Advances in the Pharmaceutical Sciences Series, 33) [Hardcover] de Lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta and Thorne, Robert G. fbm transformative insightsThe development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the bloodbrain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e. g. active passive transport across the BBB, intra brain distribution, and central systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions